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KMID : 0861020180330050073
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Korea Journal of Herbology
2018 Volume.33 No. 5 p.73 ~ p.79
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Anti-inflammatory Activity of the Methanol Extract from the Stem of Coriandrum Sativum in RAW 264.7 Cells
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Jung Ji-Yun
Park Chung-A
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Abstract
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Objectives : Coriandrum sativum is a medicinal herb that is used to enhance organoleptic quality and food flavor and as source of natural antioxidants. This research investigated the anti-inflammatory activity of Coriandrum sativum stem methanol extract (CSSE) using RAW 264.7 cells.
Methods : Production of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, and nitric oxide (NO) in the culture supernatant, protein expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and nuclear factor-kappa B (NF-κB) in the extract were assayed.
Results : Treatment with CSSE (100 ㎍/㎖) resulted in inhibited levels of protein expression of lipopolysaccharide- (LPS-) induced iNOS, COX-2, and NF-κB as well as production of TNF-α, IL-1β, IL-6, and NO induced by LPS.
Conclusions : These results demonstrate that CSSE exhibits anti-inflammatory activities via decreasing production of pro-inflammatory mediators through suppression of the pathways of NF-κB in LPS-induced RAW 264.7 cells. Thus, CSSE may have therapeutic potential for a variety of inflammation-mediated diseases.
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KEYWORD
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Coriandrum sativum stem, Anti-inflammation, Nuclear factor-kappa B, pro-inflammatory mediators
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